2017

 

178. de Almeida, A.,  Mósca, A.F.,  Wragg, D.,  Wenzel, M.,  Kavanagh, P.,  Barone, G.,  Leoni, S.,  Soveral, G.,  Casini, A. (2017) The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chemical Communications. DOI: 10.1039/c7cc00318h

177. Soveral, G., Casini, A., Aquaporin modulators: a patent review (2010–2015). (2017) Expert Opinion on Therapeutic Patents. DOI: 10.1080/13543776.2017.1236085

176. Medrano, M.A., Morais, M., Ferreira, V.F.C., Correia, J.D.G, Paulo, A., Santos, I., Navarro-Ranninger, C., Valdes, A.A., Casini, A., Mendes, F., Quiroga, A.G. (2017) Nonconventional trans-platinum omplexes functionalized  with RDG peptides: chemical and cytotoxicity studies. European Journal of Inorganic Chemistry. DOI: 10.1002/ejic.201700072

175. Han, J., Permentier, H., Groothuis, G.M.M., Bischoff, R., Kühn, F.E., Horvatovich, P., Casini A. (2017) Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. Chemical Communications; DOI: 10.1039/C6CC08937B

 

2016

 

174. Hahn, E.M, Estrada-Ortiz, N, Han, J., Ferreira, V.F.C, Kapp, T.G., Correia, J.D.G., Casini A., Kühn, F.E. (2016) Functionalization of Ruthenum(II) Terpyridine complexes with cyclic RGD peptides to target integrin receptors in cancer cells; DOI: 10.1002/ejic.201601094

173. Muenzner, J.K., Biersack, B., Albrecht, A., Rehm, T., Lacher, U., Milius, W., Casini, A., Zhang, J.J., Ott, I., Brabec, V., Stuchlikova, O., Andronache, I.C., Schuppan, D., Kaps, L., Schobert, R., Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): a Successful Approach to Multinuclear Anticancer Drugs. (2016) Chemistry, in press DOI: 10.1002/chem.201604246

172. Soveral, G., Casini, A. Aquaporin modulators: a patent review (2010-2015). (2016) Expert Opinion on Therapeutic Patents, in press DOI: 10.1080/13543776.2017.1236085

171. Kaiser, F., Schmidt, A., Heydenreuter, W., Altmann, P.J., Casini, A., Sieber, S.A., Kühn, F.E. Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity. (2016) Journal of Inorganic Chemistry, in press DOI: 10.1002/ejic.201600811

170. Khan, R.A., de Almeida, A., Al-Farhan, K., Alsalme, A., Casini, A., Ghazzali, M., Reedijk, J. Transition-metal norharmane compounds as possible cytotoxic agents: New insights based on a coordination chemistry perspective. (2016) Journal of Inorganic Biochemistry, in press DOI: 10.1016/j.jinorgbio.2016.07.001

169. Gabbiani, C., Pratesi, A., Marchetti, L., Casini, A., Leoni, P., Pillozzi, S., Crociani, O., Bartoli, G., Messori, L. Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. (2016) Journal of Inorganic Biochemistry, in press DOI: 10.1016/j.jinorgbio.2016.06.024

168. Spinello, A., De Almeida, A., Casini, A., Barone, G. The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury(II): A molecular dynamics study (2016) Journal of Inorganic Biochemistry, 160, pp. 78-84. DOI: 10.1016/j.jinorgbio.2015.11.027

167. Nave, M., Castro, R.E., Rodrigues, C.M.P., Casini, A., Soveral, G., Gaspar, M.M. Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells (2016) Nanomedicine, 11 (14), pp. 1817-1830. DOI: 10.2217/nnm-2016-0086

166. Meier, S.M., Gerner, C., Keppler, B.K., Cinellu, M.A., Casini, A. Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects (2016) Inorganic Chemistry, 55 (9), pp. 4248-4259. DOI: 10.1021/acs.inorgchem.5b03000

165. Bazzicalupi, C., Ferraroni, M., Papi, F., Massai, L., Bertrand, B., Messori, L., Gratteri, P., Casini, A. Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: A Joint ESI MS and XRD Investigation (2016) Angewandte Chemie – International Edition, 55 (13), pp. 4256-4259. DOI: 10.1002/anie.201511999

164. Wenzel, M., de Almeida, A., Bigaeva, E., Kavanagh, P., Picquet, M., Le Gendre, P., Bodio, E., Casini, A. New Luminescent Polynuclear Metal Complexes with Anticancer Properties: Toward Structure-Activity Relationships (2016) Inorganic Chemistry, 55 (5), pp. 2544-2557. DOI: 10.1021/acs.inorgchem.5b02910

163. Schmidt, A., Molano, V., Hollering, M., Pöthig, A., Casini, A., Kühn, F.E. Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin (2016) Chemistry (Weinheim an der Bergstrasse, Germany), 22 (7), pp. 2253-2256. DOI: 10.1002/chem.201504930

162. Schmidt, A., Hollering, M., Han, J., Casini, A., Kühn, F.E. Self-assembly of highly luminescent heteronuclear coordination cages (2016) Dalton Transactions, 45 (31), pp. 12297-12300. DOI: 10.1039/c6dt02708c

161. Schmidt, A., Hollering, M., Drees, M., Casini, A., Kühn, F.E. Supramolecular: Exo -functionalized palladium cages: Fluorescent properties and biological activity (2016) Dalton Transactions, 45 (20), pp. 8556-8565. DOI: 10.1039/c6dt00654j

160. Schmidt, A., Molano, V., Hollering, M., Pöthig, A., Casini, A., Kühn, F.E. Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin (2016) Chemistry – A European Journal, in press. DOI: 10.1002/chem.201504930

159. de Almeida, A., Martins, A.P., Mósca, A.F., Wijma, H.J., Prista, C., Soveral, G., Casini, A. Exploring the gating mechanisms of aquaporin-3: New clues for the design of inhibitors? (2016) Molecular BioSystems, 12 (5), pp. 1564-1573. DOI: 10.1039/c6mb00013d

158. Citta, A., Scalcon, V., Göbel, P., Bertrand, B., Wenzel, M., Folda, A., Rigobello, M.P., Meggers, E., Casini, A. Toward anticancer gold-based compounds targeting PARP-1: A new case study (2016) RSC Advances, 6 (82), pp. 79147-79152. DOI: 10.1039/c6ra11606j

157. Tsitsa, I., Tarushi, A., Doukoume, P., Perdih, F., de Almeida, A., Papadopoulos, A., Kalogiannis, S., Casini, A., Turel, I., Psomas, G. Structure and biological activities of metal complexes of flumequine (2016) RSC Advances, 6 (23), pp. 19555-19570. DOI: 10.1039/c5ra25776j

156. Casini, A., de Almeida, A. Inorganic Compounds as Aquaporin Substrates or as Potent Inhibitors: A Coordination Chemistry Point of View Chapter in: Aquaporins in Health and Disease – New Molecular Targets for Drug Discovery Edited by: Graça Soveral , Søren Nielsen , and Angela Casini, CRC Press 2016, Pages 297–318 DOI: 10.1201/b19017-19

 

2015

 

155. Folda, A., Scalcon, V., Ghazzali, M., Jaafar, M.H., Khan, R.A., Casini, A., Citta, A., Bindoli, A., Rigobello, M.P., Al-Farhan, K., Alsalme, A., Reedijk, J. Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions (2015) Journal of Inorganic Biochemistry, 153, pp. 346-354. DOI: 10.1016/j.jinorgbio.2015.08.030

154. Bertrand, B., Citta, A., Franken, I.L., Picquet, M., Folda, A., Scalcon, V., Rigobello, M.P., Le Gendre, P., Casini, A., Bodio, E. Gold(I) NHC-based homo- and heterobimetallic complexes: Synthesis, characterization and evaluation as potential anticancer agents (2015) Journal of Biological Inorganic Chemistry, 20 (6), pp. 1005-1020. DOI: 10.1007/s00775-015-1283-1

153. Rajaratnam, R., Martin, E.K., Dörr, M., Harms, K., Casini, A., Meggers, E. Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes (2015) Inorganic Chemistry, 54 (16), pp. 8111-8120. DOI: 10.1021/acs.inorgchem.5b01349

152. Muenzner, J.K., Rehm, T., Biersack, B., Casini, A., De Graaf, I.A.M., Worawutputtapong, P., Noor, A., Kempe, R., Brabec, V., Kasparkova, J., Schobert, R. Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group (2015) Journal of Medicinal Chemistry, 58 (15), pp. 6283-6292. DOI: 10.1021/acs.jmedchem.5b00896

151. Bertrand, B., Spreckelmeyer, S., Bodio, E., Cocco, F., Picquet, M., Richard, P., Le Gendre, P., Orvig, C., Cinellu, M.A., Casini, A. Exploring the potential of gold(iii) cyclometallated compounds as cytotoxic agents: variations on the C^N theme (2015) Dalton Transactions, 44 (26), pp. 11911-11918. DOI: 10.1039/c5dt01023c

150. Cinellu, M.A., Ott, I., Casini, A. Gold Organometallics with Biological Properties (2015) Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging, pp. 117-140. DOI: 10.1002/9783527673438.ch04

149. Jacques, A., Lebrun, C., Casini, A., Kieffer, I., Proux, O., Latour, J.-M., Sénèque, O. Reactivity of Cys4 zinc finger domains with gold(III) complexes: Insights into the formation of “gold fingers” (2015) Inorganic Chemistry, 54 (8), pp. 4104-4113. DOI: 10.1021/acs.inorgchem.5b00360

148. Daum, S., Chekhun, V.F., Todor, I.N., Lukianova, N.Y., Shvets, Y.V., Sellner, L., Putzker, K., Lewis, J., Zenz, T., De Graaf, I.A.M., Groothuis, G.M.M., Casini, A., Zozulia, O., Hampel, F., Mokhir, A. Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity (2015) Journal of Medicinal Chemistry, 58 (4), pp. 2015-2024. DOI: 10.1021/jm5019548

147. Laskay, Ü.A., Garino, C., Tsybin, Y.O., Salassa, L., Casini, A. Gold finger formation studied by high-resolution mass spectrometry and in silico methods (2015) Chemical Communications, 51 (9), pp. 1612-1615. DOI: 10.1039/c4cc07490d

146. Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A. Gold(I) N-heterocyclic carbene complexes with an “activable” ester moiety: Possible biological applications (2015) Journal of Organometallic Chemistry, 775, pp. 124-129. DOI: 10.1016/j.jorganchem.2014.03.020

145. Spreckelmeyer, S., Orvig, C., Casini, A. Cellular transport mechanisms of cytotoxic metallodrugs: An overview beyond cisplatin (2014) Molecules, 19 (10), pp. 15584-15610. DOI: 10.3390/molecules191015584

 

2014

 

144. de Almeida, A., Soveral, G., Casini, A. Gold compounds as aquaporin inhibitors: New opportunities for therapy and imaging (2014) MedChemComm, 5 (10), pp. 1444-1453. DOI: 10.1039/c4md00265b

143. Hahn, E.M., Casini, A., Kühn, F.E. Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals (2014) Coordination Chemistry Reviews, 276, pp. 97-111. DOI: 10.1016/j.ccr.2014.05.021

142. Schmidt, A., Casini, A., Kühn, F.E. Self-assembled M2L4 coordination cages: Synthesis and potential applications (2014) Coordination Chemistry Reviews, 275, pp. 19-36. DOI: 10.1016/j.ccr.2014.03.037

141. Bertrand, B., de Almeida, A., Van Der Burgt, E.P.M., Picquet, M., Citta, A., Folda, A., Rigobello, M.P., Le Gendre, P., Bodio, E., Casini, A. New gold(I) organometallic compounds with biological activity in cancer cells (2014) European Journal of Inorganic Chemistry, 2014 (27), pp. 4532-4536. DOI: 10.1002/ejic.201402248

140. Madeira, A., de Almeida, A., De Graaf, C., Camps, M., Zorzano, A., Moura, T.F., Casini, A., Soveral, G. A gold coordination compound as a chemical probe to unravel aquaporin-7 function (2014) ChemBioChem, 15 (10), pp. 1487-1494. DOI: 10.1002/cbic.201402103

139. Bertrand, B., Casini, A. A golden future in medicinal inorganic chemistry: The promise of anticancer gold organometallic compounds (2014) Dalton Transactions, 43 (11), pp. 4209-4219. DOI: 10.1039/c3dt52524d

138. Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Warmerdam, E., De Jager, M.H., Groothuis, G.M.M., Picquet, M., Casini, A. Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: Synthesis and biological properties (2014) Inorganic Chemistry, 53 (4), pp. 2296-2303. DOI: 10.1021/ic403011h

137. Rubbiani, R., Salassa, L., de Almeida, A., Casini, A., Ott, I. Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors (2014) ChemMedChem, 9 (6), pp. 1205-1210. DOI: 10.1002/cmdc.201400056

136. Ahmad Khan, R., Al-Farhan, K., de Almeida, A., Alsalme, A., Casini, A., Ghazzali, M., Reedijk, J. Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells (2014) Journal of Inorganic Biochemistry, 140, pp. 1-5. DOI: 10.1016/j.jinorgbio.2014.06.019

135. Wenzel, M., Bigaeva, E., Richard, P., Le Gendre, P., Picquet, M., Casini, A., Bodio, E. New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one? (2014) Journal of Inorganic Biochemistry, 141, pp. 10-16. DOI: 10.1016/j.jinorgbio.2014.07.011

134. Serratice, M., Bertrand, B., Janssen, E.F.J., Hemelt, E., Zucca, A., Cocco, F., Cinellu, M.A., Casini, A. Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro (2014) MedChemComm, 5 (9), pp. 1418-1422. DOI: 10.1039/c4md00241e

133. Serna, A., Galán-Cobo, A., Rodrigues, C., Sánchez-Gomar, I., Toledo-Aral, J.J., Moura, T.F., Casini, A., Soveral, G., Echevarría, M. Functional Inhibition of Aquaporin-3 With a Gold-Based Compound Induces Blockage of Cell Proliferation (2014) Journal of Cellular Physiology, 229 (11), pp. 1787-1801. DOI: 10.1002/jcp.24632

132. De March, M., Demitri, N., De Zorzi, R., Casini, A., Gabbiani, C., Guerri, A., Messori, L., Geremia, S. Nitrate as a probe of cytochrome c surface: Crystallographic identification of crucial “hot spots” for protein-protein recognition (2014) Journal of Inorganic Biochemistry, 135, pp. 58-67. DOI: 10.1016/j.jinorgbio.2014.02.015

131. Frik, M., Jiménez, J., Vasilevski, V., Carreira, M., De Almeida, A., Gascón, E., Benoit, F., Sanaú, M., Casini, A., Contel, M. Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents (2014) Inorganic Chemistry Frontiers, 1 (3), pp. 231-241. DOI: 10.1039/c4qi00003j

 

2013

 

130. De Almeida, A., Oliveira, B.L., Correia, J.D.G., Soveral, G., Casini, A. Emerging protein targets for metal-based pharmaceutical agents: An update (2013) Coordination Chemistry Reviews, 257 (19-20), pp. 2689-2704. DOI: 10.1016/j.ccr.2013.01.031

129. Citta, A., Schuh, E., Mohr, F., Folda, A., Massimino, M.L., Bindoli, A., Casini, A., Rigobello, M.P. Fluorescent silver(i) and gold(i)-N-heterocyclic carbene complexes with cytotoxic properties: Mechanistic insights (2013) Metallomics, 5 (8), pp. 1006-1015. DOI: 10.1039/c3mt20260g

128. Lease, N., Vasilevski, V., Carreira, M., De Almeida, A., Sanaú, M., Hirva, P., Casini, A., Contel, M. Potential anticancer heterometallic Fe-Au and Fe-Pd agents: Initial mechanistic insights (2013) Journal of Medicinal Chemistry, 56 (14), pp. 5806-5818. DOI: 10.1021/jm4007615

127. Hartinger, C.G., Groessl, M., Meier, S.M., Casini, A., Dyson, P.J. Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs (2013) Chemical Society Reviews, 42 (14), pp. 6186-6199. DOI: 10.1039/c3cs35532b

126. Martins, A.P., Ciancetta, A., deAlmeida, A., Marrone, A., Re, N., Soveral, G., Casini, A. Aquaporin inhibition by gold(III) compounds: New insights (2013) ChemMedChem, 8 (7), pp. 1086-1092. DOI: 10.1002/cmdc.201300107

125. Avanti, C., Hinrichs, W.L.J., Casini, A., Eissens, A.C., Dam, A.V., Kedrov, A., Driessen, A.J.M., Frijlink, H.W., Permentier, H.P. The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex (2013) Journal of Pharmaceutical Sciences, 102 (6), pp. 1734-1741. DOI: 10.1002/jps.23546

124. Tasan, S., Zava, O., Bertrand, B., Bernhard, C., Goze, C., Picquet, M., Le Gendre, P., Harvey, P., Denat, F., Casini, A., Bodio, E. BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics (2013) Dalton Transactions, 42 (17), pp. 6102-6109. DOI: 10.1039/c2dt32055j

123. De Luca, A., Hartinger, C.G., Dyson, P.J., Lo Bello, M., Casini, A. A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin (2013) Journal of Inorganic Biochemistry, 119, pp. 38-42. DOI: 10.1016/j.jinorgbio.2012.08.006

122. Hanif, M., Meier, S.M., Nazarov, A.A., Risse, J., Legin, A., Casini, A., Jakupec, M.A., Keppler, B.K., Hartinger, C.G. Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes (2013) Frontiers in Chemistry, 1 (OCT), pp. 1-7. DOI: 10.3389/fchem.2013.00027

121. Guidi, F., Modesti, A., Landini, I., Nobili, S., Mini, E., Bini, L., Puglia, M., Casini, A., Dyson, P.J., Gabbiani, C., Messori, L. The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics (2013) Journal of Inorganic Biochemistry, 118, pp. 94-99. DOI: 10.1016/j.jinorgbio.2012.10.003

 

2012

 

120. Casini, A., Reedijk, J. Interactions of anticancer Pt compounds with proteins: An overlooked topic in medicinal inorganic chemistry? (2012) Chemical Science, 3 (11), pp. 3135-3144. DOI: 10.1039/c2sc20627g

119. Schuh, E., Pflüger, C., Citta, A., Folda, A., Rigobello, M.P., Bindoli, A., Casini, A., Mohr, F. Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents (2012) Journal of Medicinal Chemistry, 55 (11), pp. 5518-5528. DOI: 10.1021/jm300428v

118. Martins, A.P., Marrone, A., Ciancetta, A., Cobo, A.G., Echevarría, M., Moura, T.F., Re, N., Casini, A., Soveral, G. Targeting aquaporin function: Potent inhibition of aquaglyceroporin-3 by a gold-based compound (2012) PLoS ONE, 7 (5), art. no. e37435, . DOI: 10.1371/journal.pone.0037435

117. Casini, A. Exploring the mechanisms of metal-based pharmacological agents via an integrated approach (2012) Journal of Inorganic Biochemistry, 109, pp. 97-106. DOI: 10.1016/j.jinorgbio.2011.12.007

116. Serratrice, M., Edafe, F., Mendes, F., Scopelliti, R., Zakeeruddin, S.M., Grätzel, M., Santos, I., Cinellu, M.A., Casini, A. Cytotoxic gold compounds: Synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1 (2012) Dalton Transactions, 41 (11), pp. 3287-3293. DOI: 10.1039/c2dt11913g

115. Messori, L., Cubo, L., Gabbiani, C., Álvarez-Valdés, A., Michelucci, E., Pieraccini, G., Ríos-Luci, C., León, L.G., Padrón, J.M., Navarro-Ranninger, C., Casini, A., Quiroga, A.G. Reactivity and biological properties of a series of cytotoxic PtI 2(amine) 2 complexes, either cis or trans configured (2012) Inorganic Chemistry, 51 (3), pp. 1717-1726. DOI: 10.1021/ic202036c

114. Komeda, S., Casini, A. Next-generation anticancer metallodrugs (2012) Current Topics in Medicinal Chemistry, 12 (3), pp. 219-235. DOI: 10.2174/156802612799078964

 

2011

 

113. Stepanenko, I.N., Casini, A., Edafe, F., Novak, M.S., Arion, V.B., Dyson, P.J., Jakupec, M.A., Keppler, B.K. Conjugation of organoruthenium(ii) 3-(1h-benzimidazol-2 yl)pyrazolo[3, 4-b]pyridines and indolo[3, 2-d]benzazepines to recombinant human serum albumin: A strategy to enhance cytotoxicity in cancer cells (2011) Inorganic Chemistry, 50 (24), pp. 12669-12679. DOI: 10.1021/ic201801e

112. Gabbiani, C., Casini, A., Kelter, G., Cocco, F., Cinellu, M.A., Fiebig, H.-H., Messori, L. Mechanistic studies on two dinuclear organogold(iii) compounds showing appreciable antiproliferative properties and a high redox stability (2011) Metallomics, 3 (12), pp. 1318-1323. DOI: 10.1039/c1mt00113b

111. Vergara, E., Cerrada, E., Clavel, C., Casini, A., Laguna, M. Thiolato gold(i) complexes containing water-soluble phosphane ligands: A characterization of their chemical and biological properties (2011) Dalton Transactions, 40 (41), pp. 10927-10935. DOI: 10.1039/c1dt10892a

110. Casini, A., Messori, L. Molecular mechanisms and proposed targets for selected anticancer gold compounds (2011) Current Topics in Medicinal Chemistry, 11 (21), pp. 2647-2660. DOI: 10.2174/156802611798040732

109. Wenzel, M., Bertrand, B., Eymin, M.-J., Comte, V., Harvey, J.A., Richard, P., Groessl, M., Zava, O., Amrouche, H., Harvey, P.D., Le Gendre, P., Picquet, M., Casini, A. Multinuclear cytotoxic metallodrugs: Physicochemical characterization and biological properties of novel heteronuclear gold-titanium complexes (2011) Inorganic Chemistry, 50 (19), pp. 9472-9480. DOI: 10.1021/ic201155y

108. Nowak-Sliwinska, P., Van Beijnum, J.R., Casini, A., Nazarov, A.A., Wagnières, G., Van Den Bergh, H., Dyson, P.J., Griffioen, A.W. Organometallic ruthenium(II) arene compounds with antiangiogenic activity (2011) Journal of Medicinal Chemistry, 54 (11), pp. 3895-3902. DOI: 10.1021/jm2002074

107. Mendes, F., Groessl, M., Nazarov, A.A., Tsybin, Y.O., Sava, G., Santos, I., Dyson, P.J., Casini, A. Metal-based inhibition of poly(ADP-ribose) polymerase-the guardian angel of DNA (2011) Journal of Medicinal Chemistry, 54 (7), pp. 2196-2206. DOI: 10.1021/jm2000135

106. Mügge, C., Rothenburger, C., Beyer, A., Görls, H., Gabbiani, C., Casini, A., Michelucci, E., Landini, I., Nobili, S., Mini, E., Messori, L., Weigand, W. Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors (2011) Dalton Transactions, 40 (9), pp. 2006-2016. DOI: 10.1039/c0dt00845a

105. Ang, W.H., Casini, A., Sava, G., Dyson, P.J. Organometallic ruthenium-based antitumor compounds with novel modes of action (2011) Journal of Organometallic Chemistry, 696 (5), pp. 989-998. DOI: 10.1016/j.jorganchem.2010.11.009

104. Snelders, D.J.M., Casini, A., Edafe, F., Van Koten, G., Klein Gebbink, R.J.M., Dyson, P.J. Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties (2011) Journal of Organometallic Chemistry, 696 (5), pp. 1108-1116. DOI: 10.1016/j.jorganchem.2010.11.025

103. Messori, L., Balerna, A., Ascone, I., Castellano, C., Gabbiani, C., Casini, A., Marchioni, C., Jaouen, G., Congiu Castellano, A. X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins (2011) Journal of Biological Inorganic Chemistry, 16 (3), pp. 491-499. DOI: 10.1007/s00775-010-0748-5

102. Gabbiani, C., Mastrobuoni, G., Sorrentino, F., Dani, B., Rigobello, M.P., Bindoli, A., Cinellu, M.A., Pieraccini, G., Messori, L., Casini, A. Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays (2011) MedChemComm, 2 (1), pp. 50-54. DOI: 10.1039/c0md00181c

 

2010

 

101. Casini, A., Temperini, C., Gabbiani, C., Supuran, C.T., Messori, L. The X-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins (2010) ChemMedChem, 5 (12), pp. 1989-1994. DOI: 10.1002/cmdc.201000331

100. Messori, L., Casini, A., Gabbiani, C., Michelucci, E., Cubo, L., Ríos-Luci, C., Padrón, J.M., Navarro-Ranninger, C., Quiroga, A.G. Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodidoplatinum(II) complex (2010) ACS Medicinal Chemistry Letters, 1 (8), pp. 381-385. DOI: 10.1021/ml100081e

99. Cinellu, M.A., Maiore, L., Manassero, M., Casini, A., Arca, M., Fiebig, H.-H., Kelter, G., Michelucci, E., Pieraccini, G., Gabbiani, C., Messori, L. [Au2(phen2Me)2(μ-O)2] (PF6)2, a novel dinuclear gold(III) complex showing excellent antiproliferative properties (2010) ACS Medicinal Chemistry Letters, 1 (7), pp. 336-339. DOI: 10.1021/ml100097f

98. Pelletier, F., Comte, V., Massard, A., Wenzel, M., Toulot, S., Richard, P., Picquet, M., Le Gendre, P., Zava, O., Edafe, F., Casini, A., Dyson, P.J. Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: Relationships between structural and biological properties (2010) Journal of Medicinal Chemistry, 53 (19), pp. 6923-6933. DOI: 10.1021/jm1004804

97. Casini, A., Hartinger, C.G., Nazarov, A.A., Dyson, P.J. Organometallic antitumour agents with alternative modes of action (2010) Topics in Organometallic Chemistry, 32, pp. 57-80. DOI: 10.1007/978-3-642-13185-1_3

96. Cubo, L., Groessl, M., Dyson, P.J., Quiroga, A.G., Navarro-Ranninger, C., Casini, A. Proteins as possible targets for cytotoxic trans-platinum(II) complexes with aliphatic amine ligands: Further exceptions to the DNA paradigm (2010) ChemMedChem, 5 (8), pp. 1335-1343. DOI: 10.1002/cmdc.201000104

95. Casini, A., Edafe, F., Erlandsson, M., Gonsalvi, L., Ciancetta, A., Re, N., Ienco, A., Messori, L., Peruzzini, M., Dyson, P.J. Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT (2010) Dalton Transactions, 39 (23), pp. 5556-5563. DOI: 10.1039/c003218b

94. Vergara, E., Cerrada, E., Casini, A., Zava, O., Laguna, M., Dyson, P.J. Antiproliferative activity of gold(I) alkyne complexes containing water-soluble phosphane ligands (2010) Organometallics, 29 (11), pp. 2596-2603. DOI: 10.1021/om100300a

93. Nobili, S., Mini, E., Landini, I., Gabbiani, C., Casini, A., Messori, L. Gold compounds as anticancer agents: Chemistry, cellular pharmacology, and preclinical studies (2010) Medicinal Research Reviews, 30 (3), pp. 550-580. DOI: 10.1002/med.20168

92. Gras, M., Therrien, B., Süss-Fink, G., Casini, A., Edafe, F., Dyson, P.J. Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand (2010) Journal of Organometallic Chemistry, 695 (8), pp. 1119-1125. DOI: 10.1016/j.jorganchem.2010.01.020

91. Innocenti, M., Salvietti, E., Guidotti, M., Casini, A., Bellandi, S., Foresti, M.L., Gabbiani, C., Pozzi, A., Zatta, P., Messori, L. Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of Amyloid-β1-42: An AFM study (2010) Journal of Alzheimer’s Disease, 19 (4), pp. 1323-1329. DOI: 10.3233/JAD-2010-1338

90. Groessl, M., Terenghi, M., Casini, A., Elviri, L., Lobinski, R., Dyson, P.J. Reactivity of anticancer metallodrugs with serum proteins: New insights from size exclusion chromatography-ICP-MS and ESI-MS (2010) Journal of Analytical Atomic Spectrometry, 25 (3), pp. 305-313. DOI: 10.1039/b922701f

89. Casini, A., Diawara, M.C., Scopelliti, R., Zakeeruddin, S.M., Grätzel, M., Dyson, P.J. Synthesis, characterisation and biological properties of gold(iii) compounds with modified bipyridine and bipyridylamine ligands (2010) Dalton Transactions, 39 (9), pp. 2239-2245. DOI: 10.1039/b921019a

88. Mura, P., Camalli, M., Casini, A., Gabbiani, C., Messori, L. Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B (2010) Journal of Inorganic Biochemistry, 104 (2), pp. 111-117. DOI: 10.1016/j.jinorgbio.2009.10.002

87. Vergara, E., Casini, A., Sorrentino, F., Zava, O., Cerrada, E., Rigobello, M.P., Bindoli, A., Laguna, M., Dyson, P.J. Anticancer therapeutics that target selenoenzymes: Synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands (2010) ChemMedChem, 5 (1), pp. 96-102. DOI: 10.1002/cmdc.200900370

 

2009

 

86. Spencer, J., Casini, A., Zava, O., Rathnam, R.P., Velhanda, S.K., Pfeffer, M., Callear, S.K., Hursthouse, M.B., Dyson, P.J. Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles (2009) Dalton Transactions, (48), pp. 10731-10735. DOI: 10.1039/b912096c

85. Cubo, L., Casini, A., Gabbiani, C., Mastrobuoni, G., Messori, L., Jiménez-Barbero, J., Navarro-Ranninger, C., Quiroga, A.G. Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. (2009) Chemistry (Weinheim an der Bergstrasse, Germany), 15 (36), pp. 9139-9146. DOI: 10.1002/chem.200901090

84. Cubo, L., Casini, A., Gabbiani, C., Mastrobuoni, G., Messori, L., Jiménez-Barbero, J., Navarro-Ranninger, C., Quiroga, A.G. 9 solution behaviour and biomolecular interactions of two cytotoxic transplatinum(ii) complexes bearing aliphatic amine ligands (2009) Chemistry – A European Journal, 15 (36), pp. 9139-9146. DOI: 10.1002/chem.200901090

83. Casini, A., Karotki, A., Gabbiani, C., Rugi, F., Vaák, M., Messori, L., Dyson, P.J. Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: Relevance to the mechanism of action (2009) Metallomics, 1 (5), pp. 434-441. DOI: 10.1039/b909185h

82. Grossi, C., Francese, S., Casini, A., Rosi, M.C., Luccarini, I., Fiorentini, A., Gabbiani, C., Messori, L., Moneti, G., Casamenti, F. Clioquinol decreases amyloid-β burden and reduces working memory impairment in a transgenic mouse model of alzheimer’s disease (2009) Journal of Alzheimer’s Disease, 17 (2), pp. 423-440. DOI: 10.3233/JAD-2009-1063

81. Casini, A., Kelter, G., Gabbiani, C., Cinellu, M.A., Minghetti, G., Fregona, D., Fiebig, H.-H., Messori, L. Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: A systematic study (2009) Journal of Biological Inorganic Chemistry, 14 (7), pp. 1139-1149. DOI: 10.1007/s00775-009-0558-9

80. Casini, A., Gabbiani, C., Michelucci, E., Pieraccini, G., Moneti, G., Dyson, P.J., Messori, L. Exploring metallodrug-protein interactions by mass spectrometry: Comparisons between platinum coordination complexes and an organometallic ruthenium compound (2009) Journal of Biological Inorganic Chemistry, 14 (5), pp. 761-770. DOI: 10.1007/s00775-009-0489-5

79. Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L. Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs (2009) Coordination Chemistry Reviews, 253 (11-12), pp. 1692-1707. DOI: 10.1016/j.ccr.2009.02.026

78. Gabbiani, C., Messori, L., Cinellu, M.A., Casini, A., Mura, P., Sannella, A.R., Severini, C., Majori, G., Bilia, A.R., Vincieri, F.F. Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials (2009) Journal of Inorganic Biochemistry, 103 (2), pp. 310-312. DOI: 10.1016/j.jinorgbio.2008.10.004

 

2008

 

77. Hartinger, C.G., Casini, A., Duhot, C., Tsybin, Y.O., Messori, L., Dyson, P.J. Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumour activity (2008) Journal of Inorganic Biochemistry, 102 (12), pp. 2136-2141. DOI: 10.1016/j.jinorgbio.2008.08.002

76. Chiellini, C., Casini, A., Cochet, O., Gabbiani, C., Ailhaud, G., Dani, C., Messori, L., Amri, E.Z. The influence of Auranofin, a clinically established antiarthritic gold drug, on bone metabolism: Analysis of its effects on human multipotent adipose-derived stem cells, taken as a model (2008) Chemistry and Biodiversity, 5 (8), pp. 1513-1520. DOI: 10.1002/cbdv.200890140

75. Bilia, A.R., Sannella, A.R., Vincieri, F.F., Messori, L., Casini, A., Gabbiani, C., Severini, C., Majori, G. Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity (2008) Natural Product Communications, 3 (12), pp. 1999-2002.

74. Casini, A., Gabbiani, C., Sorrentino, F., Rigobello, M.P., Bindoli, A., Geldbach, T.J., Marrone, A., Re, N., Hartinger, C.G., Dyson, P.J., Messori, L. Emerging protein targets for anticancer metallodrugs: Inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds (2008) Journal of Medicinal Chemistry, 51 (21), pp. 6773-6781. DOI: 10.1021/jm8006678

73. Ascone, I., Messori, L., Casini, A., Gabbiani, C., Balerna, A., Dell’Unto, F., Castellano, A.C. Exploiting soft and hard X-Ray absorption spectroscopy to characterize metallodrug/protein interactions: The binding of [trans-RuCl4(Im) (dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin (2008) Inorganic Chemistry, 47 (19), pp. 8629-8634. DOI: 10.1021/ic8001477

72. Gabbiani, C., Casini, A., Mastrobuoni, G., Kirshenbaum, N., Moshel, O., Pieraccini, G., Moneti, G., Messori, L., Gibson, D. Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis (2008) Journal of Biological Inorganic Chemistry, 13 (5), pp. 755-764. DOI: 10.1007/s00775-008-0361-z

71. Casini, A., Guerri, A., Gabbiani, C., Messori, L. Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: New insights from X-ray diffraction and mass spectrometry studies (2008) Journal of Inorganic Biochemistry, 102 (5-6), pp. 995-1006. DOI: 10.1016/j.jinorgbio.2007.12.022

70. Muniz-Miranda, M., Pagliai, M., Cardini, G., Messori, L., Bruni, B., Casini, A., Di Vaira, M., Schettino, V. A multi-technique approach to predicting the molecular structure of cuprizone in the gas phase and in the crystalline state (2008) CrystEngComm, 10 (4), pp. 416-422. DOI: 10.1039/b715131d

69. Gabbiani, C., Casini, A., Messori, L., Guerri, A., Cinellu, M.A., Minghetti, G., Corsini, M., Rosani, C., Zanello, P., Arca, M. Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: Relationships to biological properties (2008) Inorganic Chemistry, 47 (7), pp. 2368-2379. DOI: 10.1021/ic701254s

68. Sannella, A.R., Casini, A., Gabbiani, C., Messori, L., Bilia, A.R., Vincieri, F.F., Majori, G., Severini, C. New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications (2008) FEBS Letters, 582 (6), pp. 844-847. DOI: 10.1016/j.febslet.2008.02.028

67. Casini, A., Hartinger, C., Gabbiani, C., Mini, E., Dyson, P.J., Keppler, B.K., Messori, L. Gold(III) compounds as anticancer agents: Relevance of gold-protein interactions for their mechanism of action (2008) Journal of Inorganic Biochemistry, 102 (3), pp. 564-575. DOI: 10.1016/j.jinorgbio.2007.11.003

66. Drago, D., Bettella, M., Bolognin, S., Cendron, L., Scancar, J., Milacic, R., Ricchelli, F., Casini, A., Messori, L., Tognon, G., Zatta, P. Potential pathogenic role of β-amyloid1-42-aluminum complex in Alzheimer’s disease (2008) International Journal of Biochemistry and Cell Biology, 40 (4), pp. 731-746. DOI: 10.1016/j.biocel.2007.10.014

 

2007

 

65. Gabbiani, C., Casini, A., Messori, L. Gold(III) compounds as anticancer drugs (2007) Gold Bulletin, 40 (1), pp. 73-81.

64. Mura, P., Camalli, M., Bindoli, A., Sorrentino, F., Casini, A., Gabbiani, C., Corsini, M., Zanello, P., Rigobello, M.P., Messori, L. Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound (2007) Journal of Medicinal Chemistry, 50 (24), pp. 5871-5874. DOI: 10.1021/jm0708578

63. Pratesi, A., Zanello, P., Giorgi, G., Messori, L., Laschi, F., Casini, A., Corsini, M., Gabbiani, C., Orfei, M., Rosani, C., Ginanneschi, M. New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygen (2007) Inorganic Chemistry, 46 (24), pp. 10038-10040. DOI: 10.1021/ic701411y

62. Casini, A., Mastrobuoni, G., Terenghi, M., Gabbiani, C., Monzani, E., Moneti, G., Casella, L., Messori, L. Ruthenium anticancer drugs and proteins: A study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c (2007) Journal of Biological Inorganic Chemistry, 12 (8), pp. 1107-1117. DOI: 10.1007/s00775-007-0280-4

61. Casini, A., Gabbiani, C., Mastrobuoni, G., Pellicani, R.Z., Intini, F.P., Arnesano, F., Natile, G., Moneti, G., Francese, S., Messori, L. Insights into the molecular mechanisms of protein platination from a case study: The reaction of anticancer platinum(II) iminoethers with horse heart cytochrome C (2007) Biochemistry, 46 (43), pp. 12220-12230. DOI: 10.1021/bi701516q

60. Hartinger, C.G., Ang, W.H., Casini, A., Messori, L., Keppler, B.K., Dyson, P.J. Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI (2007) Journal of Analytical Atomic Spectrometry, 22 (8), pp. 960-967. DOI: 10.1039/b703350h

59. Casini, A., Mastrobuoni, G., Ang, W.H., Gabbiani, C., Pieraccini, G., Moneti, G., Dyson, P.J., Messori, L. ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes (2007) ChemMedChem, 2 (5), pp. 631-635. DOI: 10.1002/cmdc.200600258

58. Ciani, L., Casini, A., Gabbiani, C., Ristori, S., Messori, L., Martini, G. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques (2007) Biophysical Chemistry, 127 (3), pp. 213-220. DOI: 10.1016/j.bpc.2007.02.003

57. Sannella, A.R., Messori, L., Casini, A., Francesco Vincieri, F., Bilia, A.R., Majori, G., Severini, C. Antimalarial properties of green tea (2007) Biochemical and Biophysical Research Communications, 353 (1), pp. 177-181. DOI: 10.1016/j.bbrc.2006.12.005

56. Cini, R., Defazio, S., Tamasi, G., Casolaro, M., Messori, L., Casini, A., Morpurgo, M., Hursthouse, M. fac-{Ru(CO)3}2+-core complexes and design of metal-based drugs. Synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological media (2007) Inorganic Chemistry, 46 (1), pp. 79-92. DOI: 10.1021/ic060755s

55. Messori, L., Casini, A., Gabbiani, C., Sorace, L., Muniz-Miranda, M., Zatta, P. Unravelling the chemical nature of copper cuprizone (2007) Dalton Transactions, (21), pp. 2112-2114. DOI: 10.1039/b701896g

54. Casini, A., Mastrobuoni, G., Temperini, C., Gabbiani, C., Francese, S., Moneti, G., Supuran, C.T., Scozzafava, A., Messori, L. ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme (2007) Chemical Communications, (2), pp. 156-158. DOI: 10.1039/b611122j

 

2006

 

53. Casini, A., Cinellu, M.A., Minghetti, G., Gabbiani, C., Coronnello, M., Mini, E., Messori, L. Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands (2006) Journal of Medicinal Chemistry, 49 (18), pp. 5524-5531. DOI: 10.1021/jm060436a

52. Messori, L., Gabbiani, C., Casini, A., Siragusa, M., Vincieri, F.F., Bilia, A.R. The reaction of artemisinins with hemoglobin: A unified picture (2006) Bioorganic and Medicinal Chemistry, 14 (9), pp. 2972-2977. DOI: 10.1016/j.bmc.2005.12.038

51. Casini, A., Gabbiani, C., Mastrobuoni, G., Messori, L., Moneti, G., Pieraccini, G. Exploring metallodrug-protein interactions by ESI mass spectrometry: the reaction of anticancer platinum drugs with horse heart cytochrome c. (2006) ChemMedChem, 1 (4), pp. 413-417. DOI: 10.1002/cmdc.200500079

50. Calderone, V., Casini, A., Mangani, S., Messori, L., Orioli, P.L. Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase (2006) Angewandte Chemie – International Edition, 45 (8), pp. 1267-1269. DOI: 10.1002/anie.200502599

 

2005

 

49. Mincione, F., Starnotti, M., Masini, E., Bacciottini, L., Scrivanti, C., Casini, A., Vullo, D., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma (2005) Bioorganic and Medicinal Chemistry Letters, 15 (17), pp. 3821-3827. DOI: 10.1016/j.bmcl.2005.06.054

48. Pastorekova, S., Vullo, D., Casini, A., Scozzafava, A., Pastorek, J., Nishimori, I., Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides (2005) Journal of Enzyme Inhibition and Medicinal Chemistry, 20 (3), pp. 211-217. DOI: 10.1080/14756360400028101

47. De Simone, G., Di Fiore, A., Menchise, V., Pedone, C., Antel, J., Casini, A., Scozzafava, A., Wurl, M., Supuran, C.T. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies (2005) Bioorganic and Medicinal Chemistry Letters, 15 (9), pp. 2315-2320. DOI: 10.1016/j.bmcl.2005.03.032

46. Di Fiore, A., De Simone, G., Menchise, V., Pedone, C., Casini, A., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (2005) Bioorganic and Medicinal Chemistry Letters, 15 (7), pp. 1937-1942. DOI: 10.1016/j.bmcl.2005.01.086

45. Winum, J.-Y., Dogné, J.-M., Casini, A., De Leval, X., Montero, J.-L., Scozzafava, A., Vullo, D., Innocenti, A., Supuran, C.T. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties (2005) Journal of Medicinal Chemistry, 48 (6), pp. 2121-2125. DOI: 10.1021/jm0494826

 

2004

 

44. Zimmerman, S., Innocenti, A., Casini, A., Ferry, J.G., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides (2004) Bioorganic and Medicinal Chemistry Letters, 14 (24), pp. 6001-6006. DOI: 10.1016/j.bmcl.2004.09.085

43. Švastová, E., Hulíková, A., Rafajová, M., Zat’Ovičová, M., Gibadulinová, A., Casini, A., Cecchi, A., Scozzafava, A., Supuran, C.T., Pastorek, J., Pastoreková, S. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Letters, 577 (3), pp. 439-445. DOI: 10.1016/j.febslet.2004.10.043

42. Innocenti, A., Casini, A., Alcaro, M.C., Papini, A.M., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthiourea library (2004) Journal of Medicinal Chemistry, 47 (21), pp. 5224-5229. DOI: 10.1021/jm049692i

41. Supuran, C.T., Casini, A., Mastrolorenzo, A., Scozzafava, A. COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents (2004) Mini-Reviews in Medicinal Chemistry, 4 (6), pp. 625-632.

40. Lehtonen, J.M., Parkkila, S., Vullo, D., Casini, A., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: A novel target for the drug design (2004) Bioorganic and Medicinal Chemistry Letters, 14 (14), pp. 3757-3762. DOI: 10.1016/j.bmcl.2004.04.106

39. Bonnac, L., Innocent, A., Winum, J.-Y., Casini, A., Montero, J.-L., Scozzafava, A., Barragan, V., Supuran, C.T. Carbonic anhydrase inhibitors: Aliphatic N-phosphorylated sulfamates – A novel zinc-anchoring group leading to nanomolar inhibitors (2004) Journal of Enzyme Inhibition and Medicinal Chemistry, 19 (3), pp. 275-278. DOI: 10.1080/14756360410001689522

38. De Leval, X., Ilies, M., Casini, A., Dogné, J.-M., Scozzafava, A., Masini, E., Mincione, F., Starnotti, M., Supuran, C.T. Carbonic anhydrase inhibitors: Synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity (2004) Journal of Medicinal Chemistry, 47 (11), pp. 2796-2804. DOI: 10.1021/jm031116j

37. Abbate, F., Casini, A., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide (2004) Bioorganic and Medicinal Chemistry Letters, 14 (9), pp. 2357-2361. DOI: 10.1016/j.bmcl.2004.01.096

36. Dogné, J.-M., de Leval, X., Hanson, J., Frederich, M., Lambermont, B., Ghuysen, A., Casini, A., Masereel, B., Ruan, K.-H., Pirotte, B., Kolh, P. New developments on thromboxane and prostacyclin modulators Part 1: Thromboxane modulators (2004) Current Medicinal Chemistry, 11 (10), pp. 1223-1241.

35. Pastorekova, S., Casini, A., Scozzafava, A., Vullo, D., Pastorek, J., Supuran, C.T. Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX (2004) Bioorganic and Medicinal Chemistry Letters, 14 (4), pp. 869-873. DOI: 10.1016/j.bmcl.2003.12.029

34. Weber, A., Casini, A., Heine, A., Kuhn, D., Supuran, C.T., Scozzafava, A., Klebe, G. Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib: New Pharmacological Opportunities Due to Related Binding Site Recognition (2004) Journal of Medicinal Chemistry, 47 (3), pp. 550-557. DOI: 10.1021/jm030912m

33. Lehtonen, J., Shen, B., Vihinen, M., Casini, A., Scozzafava, A., Supuran, C.T., Parkkila, A.-K., Saarnio, J., Kivelä, A.J., Waheed, A., Sly, W.S., Parkkila, S. Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family (2004) Journal of Biological Chemistry, 279 (4), pp. 2719-2727. DOI: 10.1074/jbc.M308984200

32. Abbate, F., Casini, A., Owa, T., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX (2004) Bioorganic and Medicinal Chemistry Letters, 14 (1), pp. 217-223. DOI: 10.1016/j.bmcl.2003.09.062

31. Winum, J.-Y., Casini, A., Mincione, F., Starnotti, M., Montero, J.-L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-D- glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits (2004) Bioorganic and Medicinal Chemistry Letters, 14 (1), pp. 225-229. DOI: 10.1016/j.bmcl.2003.09.063

30. Abbate, F., Winum, J.-Y., Potter, B.V.L., Casini, A., Montero, J.-L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase (2004) Bioorganic and Medicinal Chemistry Letters, 14 (1), pp. 231-234. DOI: 10.1016/j.bmcl.2003.09.064

29. Supuran, C.T., Vullo, D., Manole, G., Casini, A., Scozzafava, A. Designing of novel carbonic anhydrase inhibitors and activators (2004) Current Medicinal Chemistry: Cardiovascular and Hematological Agents, 2 (1), pp. 49-68. DOI: 10.2174/1568016043477305

28. Abbate, F., Coetzee, A., Casini, A., Ciattini, S., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride (2004) Bioorganic and Medicinal Chemistry Letters, 14 (2), pp. 337-341. DOI: 10.1016/j.bmcl.2003.11.014

 

2003

 

27. Winum, J.-Y., Vullo, D., Casini, A., Montero, J.-L., Scozzafava, A., Supuran, C.T. Carbonic Anhydrase Inhibitors: Inhibition of Transmembrane, Tumor-Associated Isozyme IX, and Cytosolic Isozymes I and II with Aliphatic Sulfamates (2003) Journal of Medicinal Chemistry, 46 (25), pp. 5471-5477. DOI: 10.1021/jm030911u

26. Supuran, C.T., Casini, A., Scozzafava, A. Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents (2003) Medicinal Research Reviews, 23 (5), pp. 535-558. DOI: 10.1002/med.10047

25. Casini, A., Scozzafava, A., Mincione, F., Menabuoni, L., Starnotti, M., Supuran, C.T. Carbonic anhydrase inhibitors: Topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide (2003) Bioorganic and Medicinal Chemistry Letters, 13 (17), pp. 2867-2873. DOI: 10.1016/S0960-894X(03)00580-8

24. Mastrolorenzo, A., Zuccati, G., Massi, D., Gabrielli, M.G., Casini, A., Scozzafava, A., Supuran, C.T. Immunohistochemical study of carbonic anhydrase isozymes in human skin (2003) European Journal of Dermatology, 13 (5), pp. 440-444.

23. Casini, A., Abbate, F., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide – Two heads are better than one? (2003) Bioorganic and Medicinal Chemistry Letters, 13 (16), pp. 2759-2763. DOI: 10.1016/S0960-894X(03)00508-0

22. Casini, A., Caccia, S., Scozzafava, A., Supuran, C.T. Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II (2003) Bioorganic and Medicinal Chemistry Letters, 13 (16), pp. 2765-2768. DOI: 10.1016/S0960-894X(03)00507-9

21. Abbate, F., Casini, A., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors (2003) Journal of Enzyme Inhibition and Medicinal Chemistry, 18 (4), pp. 303-308. DOI: 10.1080/1475636031000119337

20. Winum, J.-Y., Vullo, D., Casini, A., Montero, J.-L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors (2003) Journal of Medicinal Chemistry, 46 (11), pp. 2197-2204. DOI: 10.1021/jm021124k

19. Casini, A., Winum, J.-Y., Montero, J.-L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of cytosolic isozymes I and II with sulfamide derivatives (2003) Bioorganic and Medicinal Chemistry Letters, 13 (5), pp. 837-840. DOI: 10.1016/S0960-894X(03)00028-3

18. Casini, A., Antel, J., Abbate, F., Scozzafava, A., David, S., Waldeck, H., Schäfer, S., Supuran, C.T. Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV (2003) Bioorganic and Medicinal Chemistry Letters, 13 (5), pp. 841-845. DOI: 10.1016/S0960-894X(03)00029-5

17. Supuran, C.T., Scozzafava, A., Casini, A. Carbonic anhydrase inhibitors (2003) Medicinal Research Reviews, 23 (2), pp. 146-189. DOI: 10.1002/med.10025

 

2002

 

16. Casini, A., Scozzafava, A., Supuran, C.T. Cysteine-modifying agents: A possible approach for effective anticancer and antiviral drugs (2002) Environmental Health Perspectives, 110 (SUPPL. 5), pp. 801-806.

15. Maestrelli, F., Mura, P., Casini, A., Mincione, F., Scozzafava, A., Supuran, C.T. Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents (2002) Journal of Pharmaceutical Sciences, 91 (10), pp. 2211-2219. DOI: 10.1002/jps.10215

14. Casini, A., Scozzafava, A., Supuran, C.T. Sulfonamide derivatives with protease inhibitory action as anticancer, anti-inflammatory and antiviral agents (2002) Expert Opinion on Therapeutic Patents, 12 (9), pp. 1307-1327. DOI: 10.1517/13543776.12.9.1307

13. Casini, A., Mincione, F., Vullo, D., Menabuoni, L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide scaffold (2002) Journal of Enzyme Inhibition and Medicinal Chemistry, 17 (1), pp. 9-18. DOI: 10.1080/14756360290018602

12. Casini, A., Scozzafava, A., Mastrolorenzo, A., Supuran, C.T. Sulfonamides and sulfonylated derivatives as anticancer agents (2002) Current Cancer Drug Targets, 2 (1), pp. 55-75. DOI: 10.2174/1568009023334060

11. Scozzafava, A., Casini, A., Supuran, C.T. Targeting cysteine residues of biomolecules: New approaches for the design of antiviral and anticancer drugs (2002) Current Medicinal Chemistry, 9 (12), pp. 1167-1185.

 

2001

 

10. Casini, A., Messori, L., Orioli, P., Gielen, M., Kemmer, M., Willem, R. Interactions of two cytotoxic organotin(IV) compounds with calf thymus DNA (2001) Journal of Inorganic Biochemistry, 85 (4), pp. 297-300. DOI: 10.1016/S0162-0134(01)00215-X

9. Casini, A., Mincione, F., Ilies, M.A., Menabuoni, L., Scozzafava, A., Supuran, C.T. Carbonic anhydrase inhibitors: Synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties (2001) Journal of Enzyme Inhibition, 16 (2), pp. 113-123.

8. Mincione, F., Starnotti, M., Menabuoni, L., Scozzafava, A., Casini, A., Supuran, C.T. Carbonic anhydrase inhibitors: 4-Sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties (2001) Bioorganic and Medicinal Chemistry Letters, 11 (13), pp. 1787-1791. DOI: 10.1016/S0960-894X(01)00303-1

7. Mura, P., Casini, A., Marcon, G., Messori, L. Synthesis, molecular structure and solution chemistry of the iridium(III) complex imidazolium [trans(bisimidazole)tetrachloro iridate(III)] (IRIM) (2001) Inorganica Chimica Acta, 312 (1-2), pp. 74-80. DOI: 10.1016/S0020-1693(00)00330-3

 

2000

 

6. Casini, A., Scozzafava, A., Mincione, F., Menabuoni, L., Ilies, M.A., Supuran, C.T. Carbonic anhydrase inhibitors: Water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects (2000) Journal of Medicinal Chemistry, 43 (25), pp. 4884-4892. DOI: 10.1021/jm001051+

5. Marcon, G., Casini, A., Mura, P., Messori, L., Bergamo, A., Orioli, P. Biological properties of IRIM, the iridium(III) analogue of (imidazolium (bisimidazole) tetrachlororuthenate) (ICR) (2000) Metal-Based Drugs, 7 (4), pp. 195-200.

4. Ottaviani, M.F., Furini, F., Casini, A., Turro, N.J., Jockusch, S., Tomalia, D.A., Messori, L. Formation of supramolecular structures between DNA and starburst dendrimers studied by EPR, CD, UV, and melting profiles (2000) Macromolecules, 33 (21), pp. 7842-7851. DOI: 10.1021/ma000877i

3. Ilies, M., Supuran, C.T., Scozzafava, A., Casini, A., Mincione, F., Menabuoni, L., Caproiu, M.T., Maganu, M., Banciu, M.D. Carbonic anhydrase inhibitors: Sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions (2000) Bioorganic and Medicinal Chemistry, 8 (8), pp. 2145-2155. DOI: 10.1016/S0968-0896(00)00143-7

2. Messori, L., Casini, A., Vullo, D., Haroutiunian, S.G., Dalian, E.B., Orioli, P. Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA (2000) Inorganica Chimica Acta, 303 (2), pp. 283-286. DOI: 10.1016/S0020-1693(99)00528-9

1. Gallori, E., Vettori, C., Alessio, E., Vilchez, F.G., Vilaplana, R., Orioli, P., Casini, A., Messori, L. DNA as a possible target for antitumor ruthenium(III) complexes: A spectroscopic and molecular biology study of the interactions of two representative antineoplastic ruthenium(III) complexes with DNA (2000) Archives of Biochemistry and Biophysics, 376 (1), pp. 156-162. DOI: 10.1006/abbi.1999.1654